store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Girinimbine (Girinimbin) is a carbazole alkaloid isolated from the plants M. koenigii, M. koenigii and Murraya koenigii.Girinimbine has a wide range of biological effects, including apoptosis, antitrypanosomal, antiplatelet, antimicrobial, anti-inflammatory, antioxidant and antitumor activities. Girinimbine has a variety of biological effects, including apoptosis, antitrypanosomal, antibacterial, anti-inflammatory, antioxidant and antitumor activities.
説明 | Girinimbine (Girinimbin) is a carbazole alkaloid isolated from the plants M. koenigii, M. koenigii and Murraya koenigii.Girinimbine has a wide range of biological effects, including apoptosis, antitrypanosomal, antiplatelet, antimicrobial, anti-inflammatory, antioxidant and antitumor activities. Girinimbine has a variety of biological effects, including apoptosis, antitrypanosomal, antibacterial, anti-inflammatory, antioxidant and antitumor activities. |
In vitro |
Girinimbine (1-400 µM; 24-72 h; HepG2 cells) exhibits IC50 values of 61 µM, 56 µM, and 40 µM, reducing the viability of HepG2 cells at 24, 48, and 72 hours, respectively.[1] Girinimbine (10-100 µM; 24-48 h; HepG2 cells) increases LDH leakage in both concentration- and time-dependent manner in HepG2 cells.[1] Girinimbine (56 µM; 24-48 h; HepG2 cells) treatment results in DNA fragmentation and elevates levels of caspase-3 in HepG2 cells.[1] Girinimbine (56 µM; 12-48 h) treatment also displays a time-dependent accumulation of the Sub-G0/G1 peak (hypodiploid) and caused G0/G1-phase arrest.[1] Girinimbine exhibits a potent antitrypanosomal activity, with an IC50 value of 10.16 µg/mL.[3] |
In vivo |
Girinimbine (10-100 mg/kg; orally gavage; once; Male ICR mice) pretreatment effectively reduces total leukocyte migration and lowers pro-inflammatory cytokine (IL-1β, TNF-α) levels in the peritoneal fluid.[2] Girinimbine (20 μg/mL; 24 h; zebrafish embryos) shows a significant distribution of apoptotic cells in embryos.[2] |
別名 | Girinimbin |
分子量 | 263.33 |
分子式 | C18H17NO |
CAS No. | 23095-44-5 |
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Girinimbine 23095-44-5 Apoptosis Microbiology/Virology oxidation-reduction Antioxidant Antibacterial Girinimbin Inhibitor inhibitor inhibit