Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PF-3758309 hydrochloride (PF-03758309 hydrochloride) , is a PAK4 inhibitor, is also a n orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PF-3758309 hydrochloride binds to PAK4, inhibiting PAK4 activity and cancer cell growth. PAK4, a serine/threonine kinase belonging to the p21-activated kinase (PAK) family, is often upregulated in a variety of cancer cell types and plays an important role in cancer cell motility, proliferation, and survival.
説明 | PF-3758309 hydrochloride (PF-03758309 hydrochloride) , is a PAK4 inhibitor, is also a n orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PF-3758309 hydrochloride binds to PAK4, inhibiting PAK4 activity and cancer cell growth. PAK4, a serine/threonine kinase belonging to the p21-activated kinase (PAK) family, is often upregulated in a variety of cancer cell types and plays an important role in cancer cell motility, proliferation, and survival. |
ターゲット&IC50 | PAK3:99 nM (IC50), PAK2:190 nM (IC50), PAK1:13.7 nM (Ki), PAK4:18.7 nM (Ki), PAK4:2.7 nM (Kd), PAK6:17.1 nM (Ki), PAK5:18.1 nM (Ki) |
別名 | PF-03758309 hydrochloride |
分子量 | 527.08 |
分子式 | C25H31ClN8OS |
CAS No. | 1279034-84-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (85.37 mM)
You can also refer to dose conversion for different animals. 詳細
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PF-3758309 hydrochloride 1279034-84-2 Apoptosis Cytoskeletal Signaling PAK growth PF3758309 hydrochloride PF 3758309 Hydrochloride p21 activated kinases proliferation survival PF-3758309 Hydrochloride PF-03758309 hydrochloride signaling PF 03758309 ATP-competitive PF 3758309 hydrochloride oncogenic PF03758309 Hydrochloride PF3758309 PF-03758309 PF03758309 PF 3758309 PF-03758309 Hydrochloride inhibit tumor PF3758309 Hydrochloride PF-3758309 PF 03758309 Hydrochloride Inhibitor inhibitor