Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IDH889 is a brain penetrant, an allosteric and mutant specific IDH1 inhibitor. IDH889 has effective selectivity for IDH1 R132* mutations (IC50s: 0.02 μM, 0.072 μM, and 1.38 μM for IDH1R132H, IDH1R132C, and IDH1wt).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 26,500 |
5 mg | 在庫あり | ¥ 57,000 |
10 mg | 在庫あり | ¥ 95,000 |
25 mg | 在庫あり | ¥ 158,500 |
50 mg | 約6-8 週間 | ¥ 225,500 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 62,500 |
説明 | IDH889 is a brain penetrant, an allosteric and mutant specific IDH1 inhibitor. IDH889 has effective selectivity for IDH1 R132* mutations (IC50s: 0.02 μM, 0.072 μM, and 1.38 μM for IDH1R132H, IDH1R132C, and IDH1wt). |
ターゲット&IC50 | IDH1 (R132C):0.072 μM, IDH1 (R132H):0.02 μM, IDH1 (WT):1.38 μM |
In vitro | IDH889 displays effective cellular inhibition of R-2-hydroxyglutarate (2-HG) production (IC50: 0.014 μM). |
分子量 | 436.48 |
分子式 | C23H25FN6O2 |
CAS No. | 1429179-07-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/ml (137.46 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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IDH889 1429179-07-6 Metabolism Dehydrogenase Inhibitor inhibit Isocitrate Dehydrogenase (IDH) IDH 889 IDH-889 inhibitor