Powder: -20°C for 3 years | In solvent: -80°C for 1 year
INT-777 (S-EMCA) is a potent TGR5 agonist with an EC50 of 0.82 μM. INT-777 (S-EMCA) inhibits NLRP5-ASC inflammasome-mediated neuroinflammation via the TGR3/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats.
ターゲット&IC50 | TGR5:0.82 μM(EC50) |
別名 | S-EMCA |
分子量 | 450.65 |
分子式 | C27H46O5 |
CAS No. | 1199796-29-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 50 mg/mL (110.95 mM)
DMSO: 30 mg/mL (66.57 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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INT-777 1199796-29-6 GPCR/G Protein GPCR19 INT777 INT 777 S-EMCA Inhibitor inhibitor inhibit