store under nitrogen,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Indomethacin sodium hydrate (Indometacin sodium hydrate) is an orally active, competitive and reversible COX1/2 inhibitor with potential anti-inflammatory activity in induced migraines, induced gastrointestinal injuries, and may be used in studies of increased intracranial pressure secondary to severe traumatic brain injury and rheumatoid arthritis in adults.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
500 mg | 在庫あり | ¥ 9,500 | |||
1 g | 在庫あり | ¥ 11,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 9,000 |
説明 | Indomethacin sodium hydrate (Indometacin sodium hydrate) is an orally active, competitive and reversible COX1/2 inhibitor with potential anti-inflammatory activity in induced migraines, induced gastrointestinal injuries, and may be used in studies of increased intracranial pressure secondary to severe traumatic brain injury and rheumatoid arthritis in adults. |
In vitro | In 3LL-D122 cells, Indomethacin sodium hydrate (0, 20, 50, 100, and 150 μM; 24 hours) inhibited cell viability, with inhibition observed at 20 mM and 50% inhibition at 60 mM[2]. |
In vivo | In male Sprague-Dawley rats, Indomethacin sodium hydrate (0.01-10 mg/kg; oral administration; for 3 hours) inhibited carrageenan-induced paw edema and hyperalgesia in a dose-dependent manner, with an ED50 of 2.0 mg/kg for paw edema and 1.5 mg/kg for hyperalgesia[1]. |
別名 | Indometacin sodium hydrate |
分子量 | 433.82 |
分子式 | C19H21ClNNaO7 |
CAS No. | 74252-25-8 |
store under nitrogen,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mg/mL (11.52 mM), Sonification is recommended.
H2O: 20 mg/mL (46.10 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Indomethacin sodium hydrate 74252-25-8 Immunology/Inflammation Neuroscience COX Indometacin Sodium Indometacin sodium hydrate Inhibitor inhibitor inhibit