Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LM-1685 is a potent and selective inhibitor of COX-2 IN human monocytes and whole blood with IC50 of 0.65µM and IC50 = 4.3μM, respectively, and is a potential compound for the treatment of inflammation.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 80,500 |
5 mg | 在庫あり | ¥ 190,000 |
10 mg | 在庫あり | ¥ 259,500 |
25 mg | 在庫あり | ¥ 365,000 |
50 mg | 在庫あり | ¥ 454,500 |
100 mg | 在庫あり | ¥ 574,000 |
500 mg | 在庫あり | ¥ 1,124,500 |
説明 | LM-1685 is a potent and selective inhibitor of COX-2 IN human monocytes and whole blood with IC50 of 0.65µM and IC50 = 4.3μM, respectively, and is a potential compound for the treatment of inflammation. |
ターゲット&IC50 | COX-2 (whole blood):4.3μM, COX-2 (human monocytes):0.65 µM |
In vitro | We found that continuous exposure to cytostatic doses of CAI and LM-1685, a celecoxib analog, reduced the proliferation and survival of seven human cancer cell lines by at least one log (P < or = 0.001) over either agent alone. The supra-additive antiproliferative effects occurred throughout a range of LM-1685 doses (5-25 micromol/L) and paralleled a decrease in COX-2 activity as measured by prostaglandin E2 production. In these cells, treatment with LM-1685/CAI suppressed the extracellular signal-regulated kinase pathway within the first hour but ultimately results in high, sustained activation of ERK over a 9-day period (P = 0.0005). [1] |
別名 | LM 1685, LM1685 |
分子量 | 377.84 |
分子式 | C18H16ClNO4S |
CAS No. | 416901-58-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (238.2 mM)
Methanol: 0.9 mg/mL (2.3 mM)
You can also refer to dose conversion for different animals. 詳細
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LM-1685 416901-58-1 Immunology/Inflammation Neuroscience COX LM 1685 LM1685 Inhibitor inhibitor inhibit