Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Isorhamnetin-3-O-glucoside (Isorhamnetin-3-O-beta-D-Glucoside) inhibits the activity of alpha-glucosidase from rat intestine; it exhibits a potent rat lens aldose reductase (RLAR) inhibition in vitro, its IC(50) being 1.4 microM and has inhibitory effects of sorbitol accumulation, suggests that it is a leading compound for further study as a new drug for the prevention and/or treatment of diabetes and its complications.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 16,500 | |||
5 mg | 在庫あり | ¥ 57,000 | |||
10 mg | 在庫あり | ¥ 95,000 | |||
25 mg | 在庫あり | ¥ 190,000 | |||
50 mg | 在庫あり | ¥ 257,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 59,500 |
説明 | Isorhamnetin-3-O-glucoside (Isorhamnetin-3-O-beta-D-Glucoside) inhibits the activity of alpha-glucosidase from rat intestine; it exhibits a potent rat lens aldose reductase (RLAR) inhibition in vitro, its IC(50) being 1.4 microM and has inhibitory effects of sorbitol accumulation, suggests that it is a leading compound for further study as a new drug for the prevention and/or treatment of diabetes and its complications. |
In vitro | The inhibitory effects of compounds from Salicornia herbacea (Chenopodiaceae) on rat lens aldose reductase (RLAR) and sorbitol accumulation in streptozotocin-induced diabetic rat tissues were investigated. METHODS AND RESULTS:The various fractions from the MeOH extract of S. herbacea were tested for their effects on RLAR in vitro. Among them, the EtOAc fraction was found to exhibit a potent RLAR inhibition (IC(50)=0.75 microg/ml), from which an active principle as a potent AR inhibitor was isolated and its chemical structure was elucidated as Isorhamnetin-3-O-beta-D-Glucoside (1) by spectral analysis. Compound 1 exhibited a potent RLAR inhibition in vitro, its IC(50) being 1.4 microM. Compound 1, when administered orally at 25 mg/kg in streptozotocin (STZ)-induced diabetic rats, caused not only a significant inhibition of serum glucose concentration but also sorbitol accumulation in the lenses, red blood cells (RBC), and sciatic nerves. CONCLUSIONS:These results indicate that compound 1 from S. herbacea is a leading compound for further study as a new drug for the prevention and/or treatment of diabetes and its complications. |
植物由来 |
別名 | Isorhamnetin-3-O-beta-D-Glucoside |
分子量 | 478.4 |
分子式 | C22H22O12 |
CAS No. | 5041-82-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (522.58 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Isorhamnetin-3-O-glucoside 5041-82-7 Others Inhibitor inhibit Isorhamnetin3Oglucoside Isorhamnetin-3-O-beta-D-Glucoside Isorhamnetin 3 O glucoside Isorhamnetin-3-O-b-D-Glucoside Isorhamnetin-3-O-β-D-Glucoside inhibitor