Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JNJ 303 is a potent blocker of IKs (IC50 : 64 nM).
説明 | JNJ 303 is a potent blocker of IKs (IC50 : 64 nM). |
ターゲット&IC50 | IKs:64 nM |
In vitro | Optical mapping was used to measure action potential durations (APDs) in the presence of the IKs blocker JNJ-303 and the IKr blocker E-4031.?JNJ-303 alone did not increase APD.?However, under isoprenaline (ISO), both the application of JNJ-303 and additional E-4031 significantly increased APD.?With JNJ-303, ISO decreased APD significantly more in the epicardium as compared to the endocardium, with subsequent application E-4031 increasing mid- and endocardial APD80 more significantly than in the epicardium.?We found that β-AR stimulation significantly augmented the effect of IKs blocker JNJ-303, in contrast to the reduced effect of IKr blocker E-4031[1]. |
分子量 | 440.98 |
分子式 | C21H29ClN2O4S |
CAS No. | 878489-28-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11 mg/mL (24.94 mM)
You can also refer to dose conversion for different animals. 詳細
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JNJ 303 878489-28-2 Membrane transporter/Ion channel Potassium Channel JNJ-303 inhibit JNJ303 Inhibitor KcsA inhibitor