Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JNJ-54175446 (JNJ-5446) is a CNS-permeable and selective P2X7 receptor antagonist that attenuates the release of IL-1β/IL-18 from microglia, and may be used in the study of depression.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 在庫あり | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
説明 | JNJ-54175446 (JNJ-5446) is a CNS-permeable and selective P2X7 receptor antagonist that attenuates the release of IL-1β/IL-18 from microglia, and may be used in the study of depression. |
ターゲット&IC50 | P2X7 receptor (rat):8.81(pic50), P2X7 receptor (human):(pic50)8.46 , P2X7 receptor (human):8.46 (pIC50), P2X7 receptor (rat):8.81 (pIC50) |
In vitro | JNJ-54175446 is a selective purinergic P2X7 receptor (P2X7R) antagonist that attenuates the release of IL-1β/IL-18 from microglial cells[1]. |
In vivo | JNJ-54175446 (30 mg/kg, intraperitoneal) administered once daily significantly reduces spontaneous recurrent seizures in mice, persisting for several days after the end of treatment[1]. |
別名 | JNJ-5446 |
分子量 | 440.78 |
分子式 | C18H13ClF4N6O |
CAS No. | 1627902-21-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (113.44 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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JNJ-54175446 1627902-21-9 Membrane transporter/Ion channel Neuroscience P2X Receptor JNJ-5446 JNJ 54175446 JNJ54175446 Inhibitor inhibitor inhibit