Powder: -20°C for 3 years | In solvent: -80°C for 1 year
A-804598 is a competitive and selective P2X7 receptor antagonist (IC50: 10 nM, rat; 9 nM, mouse; 11 nM, human).
説明 | A-804598 is a competitive and selective P2X7 receptor antagonist (IC50: 10 nM, rat; 9 nM, mouse; 11 nM, human). |
ターゲット&IC50 | P2X7R (human):11 nM, P2X7R (rat):10 nM, P2X7R (rat):9 nM |
In vitro | A-804598 effectively blocked IL-1β release in the THP-1 cells (IC50: 8.5 nM). It also blocked agonist-evoked pore formation in differentiated human THP-1 cells (IC50: 8.1 nM) with similar potency as in the calcium-influx assay. [1] |
In vivo | According to the autoradiographic analysis of coronal rat brain sections, there was specific binding of [3H]-A-804598 throughout the rat brain. In the grey matter of the L4-L6 region of the rat spinal cord, it was also found that high levels of [3H]-A-804598 specific binding. [2] |
別名 | A 804598 |
分子量 | 315.37 |
分子式 | C19H17N5 |
CAS No. | 1125758-85-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 31.5 mg/mL(100 mM)
You can also refer to dose conversion for different animals. 詳細
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A-804598 1125758-85-1 Membrane transporter/Ion channel Neuroscience P2X Receptor A804598 A 804598 P2XRs Inhibitor inhibit inhibitor