Powder: -20°C for 3 years | In solvent: -80°C for 1 year
K858 Racemic (K858) is a selective mitotic kinesin Eg5 inhibitor which acts in an ATP-noncompetitive manner.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 9,000 | |||
10 mg | 在庫あり | ¥ 15,000 | |||
25 mg | 在庫あり | ¥ 30,000 | |||
50 mg | 在庫あり | ¥ 49,000 | |||
100 mg | 在庫あり | ¥ 75,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 10,000 |
説明 | K858 Racemic (K858) is a selective mitotic kinesin Eg5 inhibitor which acts in an ATP-noncompetitive manner. |
ターゲット&IC50 | EG5:1.3 μM |
In vitro | K858 is an ATP-uncompetitive inhibitor of Eg5 that is at least 150-fold more selective for Eg5 than other members of the kinesin superfamily. K858 induces mitotic arrest and growth inhibition through the activation of the Mad2-mediated spindle checkpoint. K858 induces mitotic cell death in Y cells but not in normal cells. K858 induces mitotic arrest, apoptosis, and cell growth inhibition and has no effect on microtubule polymerization. |
In vivo | K858 exhibits antitumor activity and induces mitotic arrest in a human tumor xenograft mouse model. K858 exhibits antitumor activity and induces mitotic arrest in human xenograft tumor models. [1] |
別名 | K858 Racemic, K858 |
分子量 | 277.34 |
分子式 | C13H15N3O2S |
CAS No. | 72926-24-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.7 mg/mL(100 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
K858 (Racemic) 72926-24-0 Apoptosis Cytoskeletal Signaling Kinesin inhibit K858 Racemic Inhibitor K-858 (Racemic) K 858 K-858 K858 Racemic inhibitor