Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Kumatakenin can suppress >80% of the SOS-inducing activity of Trp-P-1 at <0.06 micromol/mL.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 30,000 | |||
5 mg | 在庫あり | ¥ 73,500 | |||
10 mg | 在庫あり | ¥ 109,000 | |||
25 mg | 在庫あり | ¥ 179,000 | |||
50 mg | 在庫あり | ¥ 250,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 76,000 |
説明 | Kumatakenin can suppress >80% of the SOS-inducing activity of Trp-P-1 at <0.06 micromol/mL. |
In vitro | The methanol extract was re-extracted with hexane, dichloromethane, butanol, and water. A dichloromethane fraction showed a suppressive effect. Suppressive compounds against furylfuramide in the dichloromethane fraction were isolated by SiO(2) column chromatography and identified as 7,4'-di-O-methyleriodictyol (1), 7, 3',4'-tri-O-methyleriodictyol (2), and 3,7,4'-tri-O-methylkaempferol (3). In addition, three flavonoids, ombuine (4), pachypodol (5), and Kumatakenin (6), were isolated and identified from the dichrolomethane fraction. Compounds 1 and 3 suppressed >50% of the SOS-inducing activity at <0.6 micromol/mL, and the ID(50) values of both compounds were 0.25 micromol/mL. Compound 2 showed a weakly suppressive effect (17%) at a concentration of 0.6 micromol/mL, and compounds 4-6 did not. These compounds were also assayed with 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1), which requires liver metabolizing enzymes. Compounds 3,4,5,Kumatakenin (6) suppressed >80% of the SOS-inducing activity of Trp-P-1 at <0.06 micromol/mL, and compounds 1 and 2 suppressed 87 and 63% at a concentration of 0.3 micromol/mL. In addition, these compounds were assayed with activated Trp-P-1, and the suppressed effects of these compounds were further decreased when compared to Trp-P-1. |
植物由来 |
別名 | Jaranol, Kaempferol 3,7-O-dimethyl ether |
分子量 | 314.29 |
分子式 | C17H14O6 |
CAS No. | 3301-49-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/ml (190.9 mM)
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Kumatakenin 3301-49-3 Apoptosis Microbiology/Virology Anti-infection Jaranol ovarian Inhibitor cell inhibit Kaempferol 3,7-O-dimethyl ether cancer inhibitor