Powder: -20°C for 3 years | In solvent: -80°C for 1 year
L-Clausenamide is an alkaloid extracted from the leaves of the yellow bark (Clausena lansium (Lour) skeels) and can be used to improve cognitive function. L-Clausenamide inhibits beta-amyloid (Aβ) toxicity and prevents the formation of neurofibrillary tangles by inhibiting tau phosphorylation. L-Clausenamide has neuroprotective activity and can be used to modulate stimuli triggered by Aβ25-35. L-Clausenamide can be used to study neurological disorders like Alzheimer's disease.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 91,500 |
5 mg | 在庫あり | ¥ 223,000 |
10 mg | 在庫あり | ¥ 271,000 |
25 mg | 在庫あり | ¥ 363,000 |
50 mg | 在庫あり | ¥ 454,500 |
100 mg | 在庫あり | ¥ 574,000 |
説明 | L-Clausenamide is an alkaloid extracted from the leaves of the yellow bark (Clausena lansium (Lour) skeels) and can be used to improve cognitive function. L-Clausenamide inhibits beta-amyloid (Aβ) toxicity and prevents the formation of neurofibrillary tangles by inhibiting tau phosphorylation. L-Clausenamide has neuroprotective activity and can be used to modulate stimuli triggered by Aβ25-35. L-Clausenamide can be used to study neurological disorders like Alzheimer's disease. |
In vitro |
Reversing the overload in [Ca2+]i level stimulated by Aβ25-35 and reducing Aβ-mediated cell apoptosis in PC12 cells, (-)Clausenamide (10 and 100 μM) demonstrates its protective effects[3]. In Aβ25-35-treated PC12 cells, (-)Clausenamide (10 and 100 μM) inhibits the phosphorylation of p38 MAPK and down-regulates the expression of P53 and cleaved Caspase-3, as well as the ratio of Bax/Bcl-2[3]. |
別名 | (-)-Clausenamide |
分子量 | 297.35 |
分子式 | C18H19NO3 |
CAS No. | 201529-58-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (168.15 mM)
You can also refer to dose conversion for different animals. 詳細
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L-Clausenamide 201529-58-0 Cytoskeletal Signaling Microtubule Associated Clausenamide (-)-Clausenamide Inhibitor inhibitor inhibit