Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LASSBio-1135 is an orally effective antagonist of TRPV1 and inhibitor of TNF-α production.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 30,500 | |||
2 mg | 在庫あり | ¥ 45,500 | |||
5 mg | 在庫あり | ¥ 68,500 | |||
10 mg | 在庫あり | ¥ 104,000 | |||
25 mg | 在庫あり | ¥ 171,500 | |||
50 mg | 在庫あり | ¥ 241,000 | |||
100 mg | 在庫あり | ¥ 326,000 |
説明 | LASSBio-1135 is an orally effective antagonist of TRPV1 and inhibitor of TNF-α production. |
In vivo | Oral administration of 100 mol x Kg(-1) LASSBio-1135 markedly reduced thermal hyperalgesia induced by carrageenan, however at 10 mol x Kg(-1) only a partial reduction was observed at the 4th h. Neutrophil recruitment and TNF-α production after carrageenan stimulus was also inhibited by the treatment with LASSBio-1135.?Modulating TRPV1 and TNF-α production, two key therapeutic targets of neuropathic pain, 100 mol x Kg(-1) LASSBio-1135 was orally efficacious in reversing thermal hyperalgesia and mechanical allodynia produced by partial sciatic ligation 7-11 days after surgery without provoking hyperthermia, a common side effect of TRPV1 antagonists. |
分子量 | 286.33 |
分子式 | C18H14N4 |
CAS No. | 852453-71-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2.87 mg/mL (10.01 mM)
You can also refer to dose conversion for different animals. 詳細
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LASSBio-1135 852453-71-5 Apoptosis Membrane transporter/Ion channel TRP/TRPV Channel TNF LASSBio 1135 LASSBio1135 Inhibitor inhibitor inhibit