Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LIT-001 improves social interaction in a mouse model of autism.It is the first nonpeptide oxytocin receptor agonist with EC50 of 55 nM and Ki of 226 nM.
説明 | LIT-001 improves social interaction in a mouse model of autism.It is the first nonpeptide oxytocin receptor agonist with EC50 of 55 nM and Ki of 226 nM. |
ターゲット&IC50 | OTR:226 nM (Ki), OTR:55 nM (EC50) |
In vitro | In the in vitro signal transduction experiment, LITL-001 is an unbiased OT-R agonist, acting on the two main signal transduction pathways of this receptor, with slight antagonistic effect on V1a and agonist effect on V1b receptor, only observed at high concentration. |
In vivo | LIT-001 (10-20 mg/kg; i.p.) alleviates core symptoms in the context of autism spectrum disorders (ASD )[1]. |
分子量 | 645.7 |
分子式 | C30H34F3N7O4S |
CAS No. | 2245072-21-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 247 mg/mL (382.53 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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LIT-001 2245072-21-1 Endocrinology/Hormones GPCR/G Protein Oxytocin Receptor autism Inhibitor interaction inhibit LIT001 OXTR V1a vasopressin nonpeptide social nonbiased receptor disorders spectrum LIT 001 inhibitor