Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LMPTP Inhibitor 1 Dihydrochloride is a compound selectively targeting low molecular weight protein tyrosine phosphatase (LMPTP), exhibiting potent inhibitory activity with an IC50 value of 0.8 μM for LMPTP-A.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 16,000 | |||
5 mg | 在庫あり | ¥ 39,500 | |||
10 mg | 在庫あり | ¥ 64,000 | |||
25 mg | 在庫あり | ¥ 119,000 | |||
50 mg | 在庫あり | ¥ 172,000 | |||
100 mg | 在庫あり | ¥ 241,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 51,500 |
説明 | LMPTP Inhibitor 1 Dihydrochloride is a compound selectively targeting low molecular weight protein tyrosine phosphatase (LMPTP), exhibiting potent inhibitory activity with an IC50 value of 0.8 μM for LMPTP-A. |
ターゲット&IC50 | LMPTPA:0.8 μM |
In vitro | LMPTP INHIBITOR 1 dihydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase, with an IC50?of 0.8 μM LMPTP-A and shows more potent effect on LMPTP-A versus LMPTP-B. LMPTP inhibitor 1 dihydrochloride (10 μM) also enhances HepG2 IR phosphorylation after insulin stimulation in human HepG2 hepatocytes[1]. |
In vivo | LMPTP inhibitor 1 dihydrochloride, an orally bioavailable compound, achieves an approximate mean serum concentration of 680 nM following 0.03% w/w administration and exceeds 3 μM with 0.05% w/w dosage. Notably, it reverses diabetes in obese mice. At a concentration of 0.05% w/w, it effectively inhibits LMPTP activity, leading to a significant enhancement in glucose tolerance and a reduction in fasting insulin levels in diabetic DIO mice, with no impact on body weight[1]. |
分子量 | 517.53 |
分子式 | C28H38Cl2N4O |
CAS No. | 2310135-46-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 50 mg/mL (96.61 mM), Sonication is recommended.
DMSO: 64 mg/mL (123.66 mM)
You can also refer to dose conversion for different animals. 詳細
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