Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LP-533401 is an inhibitor of Tryptophan hydroxylase 1. It is used for regulates serotonin production in the gut.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
5 mg | 約 35 days | ¥ 177,000 |
10 mg | 約 35 days | ¥ 312,500 |
25 mg | 約 35 days | ¥ 682,000 |
説明 | LP-533401 is an inhibitor of Tryptophan hydroxylase 1. It is used for regulates serotonin production in the gut. |
In vitro | At a dose of 1 μM, LP-533401 fully suppresses serotonin production in Tph1–expressing cells [1]. |
In vivo | Mice treated repeatedly with LP-533401 (30–250 mg/kg per day) exhibit marked 5-HT content reductions in the gut, lungs, and blood, but not in the brain. Adult, healthy mice treated with the Tph-1 inhibitor LP-533401 display a 30% decrease in circulating serotonin levels, with a consequent 30% increase in osteoblast numbers. Pharmacokinetic studies in rodents show that the LP-533401 level in the brain is negligible following oral administration, indicating that it is virtually unable to cross the blood-brain barrier[1]. Lung and gut 5-HT contents decrease by 50%, after a single LP533401 dose (250 mg/kg), whereas blood 5-HT levels remain unchanged, suggesting gut and lung 5-HT synthesis[2]. Administration of LP533401 to mice injected with EL4 cells inhibits the decrement in osteoblast numbers and trabecular bone volume prolongs survial, and decreases leukemic infiltration[3]. |
分子量 | 526.48 |
分子式 | C27H22F4N4O3 |
CAS No. | 945976-43-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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LP-533401 945976-43-2 Metabolism Hydroxylase LP533401 LP 533401 Inhibitor inhibitor inhibit