Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LPA1 receptor antagonist 1(LPA1 R antagonist 1) is a selective and potent lysophosphatidic acid (LPA1) receptor antagonist (IC50 : 25 nM) for the study of idiopathic pulmonary fibrosis.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 34,000 | |||
5 mg | 在庫あり | ¥ 84,500 | |||
10 mg | 在庫あり | ¥ 135,000 | |||
25 mg | 在庫あり | ¥ 211,000 | |||
50 mg | 在庫あり | ¥ 282,500 | |||
100 mg | 在庫あり | ¥ 383,500 |
説明 | LPA1 receptor antagonist 1(LPA1 R antagonist 1) is a selective and potent lysophosphatidic acid (LPA1) receptor antagonist (IC50 : 25 nM) for the study of idiopathic pulmonary fibrosis. |
ターゲット&IC50 | LPA1:25 nM |
In vitro | Compared to Ki16425 and AM095, LPA1 receptor antagonist 1 demonstrates superior anti-proliferative activity. It exhibits the highest selectivity for LPA1 and efficiently inhibits LPA-induced NHLF proliferation and contraction[1]. Similarly, LPA1 receptor antagonist 1 (compound 2) shows highly specific inhibitory activity against LPA1, with minimal inhibition of LPA3 even at relatively high concentrations.[1]. |
In vivo | Oral dosing of LPA1 receptor antagonist 1(compound 2) to mice resulted in a dose-dependent reduction of plasma histamine levels in a murine LPA challenge model[1]. |
別名 | LPA1 R antagonist 1 |
分子量 | 482.53 |
分子式 | C28H26N4O4 |
CAS No. | 1396006-71-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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LPA1 receptor antagonist 1 1396006-71-5 GPCR/G Protein LPA Receptor LPA-1 receptor antagonist 1 LPA1 antagonist 1 LPA1 R antagonist 1 Inhibitor inhibitor inhibit