Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GRI977143 is a selective and non-lipid agonist of LPA2 (EC50 = 3.3 μM). GRI977143 inhibits the activation of caspases 3, 7, 8, and 9 and and reduces DNA fragmentation.
説明 | GRI977143 is a selective and non-lipid agonist of LPA2 (EC50 = 3.3 μM). GRI977143 inhibits the activation of caspases 3, 7, 8, and 9 and and reduces DNA fragmentation. |
ターゲット&IC50 | LPA2 receptor:3.3 μM (EC50) |
In vitro | GRI977143 (10 μM) reduces caspase 3 and 7 activation by 51% in Doxorubicin-induced apoptotic signaling in vector-transduced or LPA2-transduced MEF. GRI977143 stimulates the activation of extracellular signal-regulated kinase 1/2 and promotes the assembly of LPA2, thyroid receptor-interacting protein 6 and Na+-H+ exchange regulatory factor 2[1]. |
別名 | GRI 977143 |
分子量 | 391.44 |
分子式 | C22H17NO4S |
CAS No. | 325850-81-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45.0 mg/mL (115.0 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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GRI977143 325850-81-5 GPCR/G Protein LPA Receptor GRI 977143 GRI-977143 Inhibitor inhibitor inhibit