Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lactisole (na-PMP) is an inhibitor of the glucose-sensing receptor
説明 | Lactisole (na-PMP) is an inhibitor of the glucose-sensing receptor |
ターゲット&IC50 | Sweet taste receptor:∼4 mM |
In vitro | In MIN6 cells, in a dose-dependent manner, lactisole inhibited insulin secretion induced by sweeteners, acesulfame-K, sucralose and glycyrrhizin. The IC50 was ~4 mmol/l. Lactisole attenuated the elevation of cytoplasmic Ca2+ concentration ([Ca2+]c) evoked by sucralose and acesulfame-K but did not affect the elevation of intracellular cAMP concentration ([cAMP]c) induced by these sweeteners. Lactisole also inhibited the action of glucose in MIN6 cells. Thus, lactisole significantly reduced elevations of intracellular [NADH] and intracellular [ATP] induced by glucose, and also inhibited glucose-induced insulin secretion[1]. |
別名 | na-PMP |
分子量 | 218.18 |
分子式 | C10H11NaO4 |
CAS No. | 150436-68-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 1 mg/mL
DMSO: 45 mg/mL (206.25 mM)
DMF: 20 mg/mL
You can also refer to dose conversion for different animals. 詳細
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Lactisole 150436-68-3 Metabolism Taste receptor na-PMP Inhibitor inhibitor inhibit