Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lagociclovir (MIV-210), a nucleoside analogue, is an antiviral compound available for the treatment of HBV82 that inhibits the replication of wild-type hepatitis B virus (HBV) in human hepatocellular carcinoma cell lines that permanently express HBV.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 71,500 |
5 mg | 在庫あり | ¥ 174,000 |
10 mg | 在庫あり | ¥ 243,500 |
25 mg | 在庫あり | ¥ 363,000 |
50 mg | 在庫あり | ¥ 489,000 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 165,000 |
説明 | Lagociclovir (MIV-210), a nucleoside analogue, is an antiviral compound available for the treatment of HBV82 that inhibits the replication of wild-type hepatitis B virus (HBV) in human hepatocellular carcinoma cell lines that permanently express HBV. |
ターゲット&IC50 | HBV (3TC-R):8 μM, PMEA-R (HBV):13 μM, HBV (WT):9 μM, HBV (3TC+PMEA-R):15 μM |
In vitro |
Lagociclovir (FLG) (6 days) exhibited inhibitory activity against 3TC-R HBV, wt HBV, PMEA-R HBV and 3TC+PMEA-R HBV in transiently transfected Huh7 cells with IC50s of 8 ± 3.8, 9 ± 2.5, 13 ± 3.4 and 15 ± 6.8 μM, respectively [1]. Lagociclovir (0-100 μM; 6 days) inhibits the replication of HBV wild-type and drug-resistant mutants in transiently transfected Huh7 cells.[2] |
In vivo | Anti-HBV compound Oral administration of MIV-210 (20 or 60 mg/kg; body weight/day) induced a rapid virological response in chronically infected woodchucks, reducing serum WHV DNA levels by 4.75 log10 and 5.72 log10, respectively, in 2 weeks. MIV-210 at 20 or 60 mg/kg/day reduced the liver WHV DNA load 200- to 2,500-fold from pretreatment levels and, importantly, led to a 2.0 log10 drop in the hepatic content of WHV covalently closed circular DNA. Further, a daily dose of 10 mg/kg decreased the serum WHV load 400-fold after 4 weeks of treatment, and a dose of 5 mg/kg/day was sufficient to maintain this antiviral effect during the following 6-week period.[1] |
別名 | MIV-210 |
分子量 | 269.23 |
分子式 | C10H12FN5O3 |
CAS No. | 92562-88-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (92.86 mM)
You can also refer to dose conversion for different animals. 詳細
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Lagociclovir 92562-88-4 Microbiology/Virology HBV MIV210 MIV-210 MIV 210 Inhibitor inhibitor inhibit