keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Larazotide acetate is a synthetic peptide. It functions as a tight junction regulator and reverses leaky junctions to their normally closed state.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 9,000 | |||
5 mg | 在庫あり | ¥ 18,500 | |||
10 mg | 在庫あり | ¥ 29,500 | |||
25 mg | 在庫あり | ¥ 60,500 | |||
50 mg | 在庫あり | ¥ 90,500 | |||
100 mg | 在庫あり | ¥ 132,500 |
説明 | Larazotide acetate is a synthetic peptide. It functions as a tight junction regulator and reverses leaky junctions to their normally closed state. |
In vitro | Larazotide acetate inhibits the AT-1002-induced TEER reduction and TJ opening in Caco-2 cells and it also inhibits the redistribution and rearrangement of zonula occludens-1 (ZO-1) and actin caused by AT-1002 and gliadin fragments in Caco-2 and IEC6 cells. Larazotide acetate inhibits the translocation of a gliadin 13-mer peptide, which has been implicated in celiac disease, across Caco-2 cell monolayers. Apically applied Larazotide acetate inhibits the increase in TJ permeability elicited by basolaterally applied cytokines. |
In vivo | Larazotide acetate inhibits gliadin-induced macrophage accumulation in the intestine and preserved normal tight junction structure when tested in vivo in gliadin-sensitized HLA-HCD4/DQ8 double transgenic mice. |
分子量 | 785.89 |
分子式 | C34H59N9O12 |
CAS No. | 881851-50-9 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 16.67 mg/mL (21.21 mM), Sonication is recommended.
DMSO: 3.2 mg/mL (4.07 mM), Sonication and heating are recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Larazotide acetate 881851-50-9 Cytoskeletal Signaling Gap Junction Protein inhibit Larazotide Larazotide Acetate Inhibitor inhibitor