Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Levcromakalim (BRL 38227) is an activator of the ATP-sensitive K+ channel.
説明 | Levcromakalim (BRL 38227) is an activator of the ATP-sensitive K+ channel. |
In vitro | Levcromakalim inhibits spontaneous contractions completely in a glibenclamide-sensitive manner. LevCromakalim (5 μM) inhibits spontaneous contractions, which are recovered by glibenclamide. Levcromakalim (1, 5 and 10 μM) inhibits phasic contractions to 34±21.1%, 20.1±20.0% and 0% of the control. Glibenclamide reverses the inhibition of spontaneous isometric contractions caused by LevCromakalim (5 μM) to 84±1.5% of the control. Levcromakalim (20 and 100 μM) also inhibits oxytocin (OXT) (10 nM)-induced phasic contractions to 34±21.4% and 14±12.6% of the control [2]. LevCromakalim induces dose-dependent relaxation in both the young and old mesenteric artery (MAs); there is no difference in relaxation with age. However, the relaxation is markedly reduced in response to the high-salt (HS) diet in the old MAs (P<0.05). Maximum dilations to Levcromakalim (10-4 M) are 97 ± 3% in the young MAs versus 98 ± 1% in the young salt arteries, while dilations are 99±0.7% in the old MAs when compared with 85 ± 5% in the old salt arteries (P<0.05) [3]. |
別名 | (-)-Cromakalim, BRL 38227 |
分子量 | 286.33 |
分子式 | C16H18N2O3 |
CAS No. | 94535-50-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Insoluble
DMSO: 50 mg/mL (174.62 mM )
You can also refer to dose conversion for different animals. 詳細
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Levcromakalim 94535-50-9 Membrane transporter/Ion channel Potassium Channel KcsA BRL38227 Inhibitor (-)-Cromakalim inhibit BRL-38227 BRL 38227 Cromakalim inhibitor