Powder: -20°C for 3 years | In solvent: -80°C for 1 year
M2N12 is a potent and highly selective inhibitor of cell division cycle 25C protein phosphatase (Cdc25C, IC50 = 0.09 μM). M2N12 has anti-tumor activity. M2N12 also has promising activity against Cdc25A(IC50 = 0.53 μM) and Cdc25B(IC50 = 1.39 μM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 28,000 | |||
5 mg | 在庫あり | ¥ 57,000 | |||
10 mg | 在庫あり | ¥ 91,500 | |||
25 mg | 在庫あり | ¥ 152,500 | |||
50 mg | 在庫あり | ¥ 217,000 | |||
100 mg | 在庫あり | ¥ 294,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 62,500 |
説明 | M2N12 is a potent and highly selective inhibitor of cell division cycle 25C protein phosphatase (Cdc25C, IC50 = 0.09 μM). M2N12 has anti-tumor activity. M2N12 also has promising activity against Cdc25A(IC50 = 0.53 μM) and Cdc25B(IC50 = 1.39 μM). |
ターゲット&IC50 | KB-VIN:6.81 μM, CDC25C:0.09 μM, MCF-7 cells:4.71 μM, A549 cells:3.92 μM, MDA-MB-231 cells:4.63 μM, HBE:6.00 μM, KB:5.05 μM |
In vitro | M2N12 has cytotoxic activity against five tumor cell lines and a normal cell line including A-549(IC50 = 3.92 μM), MDA-MB-231(IC50 = 4.63 μM), KB(IC50 = 5.05 μM), KB-VIN(IC50 = 6.81 μM), MCF-7(IC50 = 4.71 μM) and HBE(IC50 = 6.00 μM)[1]. |
分子量 | 393.83 |
分子式 | C20H16ClN5O2 |
CAS No. | 2376577-06-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 8 mg/mL (20.31 mM)
You can also refer to dose conversion for different animals. 詳細
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M2N12 2376577-06-7 Metabolism Phosphatase CDK M-2N12 HBE KB-VIN A-549 Cyclin dependent kinase MCF-7 cancer Inhibitor inhibit inhibitor