store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
M443 is a potent small molecule inhibitor of MRK that inhibits radiation-induced activation of p38 and Chk2 and can be used in cancer research.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
5 mg | 約6-8 週間 | ¥ 98,000 |
25 mg | 約6-8 週間 | ¥ 305,500 |
50 mg | 約6-8 週間 | ¥ 399,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
説明 | M443 is a potent small molecule inhibitor of MRK that inhibits radiation-induced activation of p38 and Chk2 and can be used in cancer research. |
ターゲット&IC50 | MRK:<125 nM |
In vitro | The osmotic pumps were filled with a solution of 0.05 mg/ml M443 or vehicle [0.01% DMSO in PBS], and implanted into the backs of animals. The results showed that treatment with M443 alone extended the survival of mice by 5.5 days. |
In vivo | As a time-dependent irreversible MRK inhibitor, M443 (500 nM) significantly inhibits the activation of MRK, Chk2, and p38 stimulated by IR. |
分子量 | 589.61 |
分子式 | C31H30F3N7O2 |
CAS No. | 1820684-31-8 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (50.88 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
M443 1820684-31-8 Cell Cycle/Checkpoint MAPK p38 MAPK Chk M 443 M-443 Inhibitor inhibitor inhibit