Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 μM, respectively. ML-9 is a selective and effective inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK), and stromal interaction molecule 1 (STIM1) activity. ML-9 causes autophagy by stimulating autophagosome formation and inhibiting their degradation.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 8,000 | |||
10 mg | 在庫あり | ¥ 12,000 | |||
25 mg | 在庫あり | ¥ 22,500 | |||
50 mg | 在庫あり | ¥ 36,500 | |||
100 mg | 在庫あり | ¥ 54,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 8,500 |
説明 | ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 μM, respectively. ML-9 is a selective and effective inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK), and stromal interaction molecule 1 (STIM1) activity. ML-9 causes autophagy by stimulating autophagosome formation and inhibiting their degradation. |
In vitro | ML9 (50?μM; 1-4?hours) obviously enhances cleaved caspase-3 levels, reduced STIM1 protein levels by about 42%. ML9 (0-100?μM; 0-24?hours) has no reduction in cardiomyocyte viability, 50-100?μM obviously causes cell death [2]. |
分子量 | 361.29 |
分子式 | C15H18Cl2N2O2S |
CAS No. | 105637-50-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (69.2 mM)
You can also refer to dose conversion for different animals. 詳細
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ML-9 105637-50-1 Cytoskeletal Signaling PI3K/Akt/mTOR signaling Myosin Akt viability STIM1 Inhibitor ML9 MLCK caspase inhibit ML 9 cardiomyocyte inhibitor