Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JB062 is a chemical compound acting as a nonmuscle myosin inhibitor, exhibiting IC50 values of 1.6, 5.4, and >100 μM against skeletal muscle myosin, cardiac muscle myosin, and smooth muscle myosin II, respectively. It selectively exhibits cytotoxicity towards human cancer cells without affecting normal cells. The compound is applicable in research fields concerning muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy.
説明 | JB062 is a chemical compound acting as a nonmuscle myosin inhibitor, exhibiting IC50 values of 1.6, 5.4, and >100 μM against skeletal muscle myosin, cardiac muscle myosin, and smooth muscle myosin II, respectively. It selectively exhibits cytotoxicity towards human cancer cells without affecting normal cells. The compound is applicable in research fields concerning muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy. |
ターゲット&IC50 | Cardiac muscle myosin:5.4 μM, Smooth muscle myosin II:>100 μM, Skeletal muscle myosin:1.6 μM |
In vitro |
JB062 (40 μM ; 24 h) inhibited cytoplasmic division in COS-7 cells.[1] JB062 (COS-7 cells) exhibited cytotoxicity against human cancer cells but showed no cytotoxicity towards normal cells, with an IC50 value of 36 μM.[1] |
分子量 | 323.34 |
分子式 | C19H17NO4 |
CAS No. | 2417988-00-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 22.5 mg/mL (69.58 mM)
You can also refer to dose conversion for different animals. 詳細
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JB062 2417988-00-0 Cytoskeletal Signaling Myosin Inhibitor inhibitor inhibit