Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Manidipine (Iperten), a calcium channel blocker, which is dihydropyridine type. It is utilized
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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10 mg | 在庫あり | ¥ 9,000 | |||
25 mg | 在庫あり | ¥ 12,500 | |||
50 mg | 在庫あり | ¥ 20,500 | |||
100 mg | 在庫あり | ¥ 37,500 | |||
200 mg | 在庫あり | ¥ 53,500 | |||
500 mg | 在庫あり | ¥ 90,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 21,500 |
説明 | Manidipine (Iperten), a calcium channel blocker, which is dihydropyridine type. It is utilized |
ターゲット&IC50 | Ca2+ channel:2.6 nM |
In vitro | Manidipine, a Ca(2+)-channel blocker, at concentrations that lower elevated blood pressure, modulates the transcription rates of cytokine genes in the mesangial cells of humans that had been stimulated with platelet-derived growth factor BB isomer. [1] Manidipine inhibits the ET-1-induced [Ca2+]i increase by reducing both the transient and sustained Ca2+ increments in A7r5 cells and glomerular mesangial cells (MCs). Manidipine (10(-5) mol/L) potentiates ET-1-induced c-fos and c-jun expression in A7r5 cells. Manidipine is a potent inhibitor for ET-1-induced [Ca2+]i signaling and that Manidipine has multiple effects on ET-1-induced signaling, including potentiating the immediate-early gene response. [2] |
In vivo | Manidipine reduces systolic blood pressure with a slight sympathetic reflex increase in heart rate, and increases plasma nitrite/nitrates in perfused rat heart from ischemia-reperfusion damage. Manidipine combined with Simvastatin reduces creatine kinase, lactate dehydrogenase and tumor necrosis factor-alpha, and enhancement of 6-keto-PGF(1alpha) during reperfusion. [3] Manidipine hydrochloride prevents isoproterenol-induced left ventricular hypertrophy and expression of mRNA of ANP, collagen types I and type III, and fibronectin in rats with isoproterenol-induced cardiac hypertrophy. [4] Manidipine HCl increases renal blood flow (RBF) by dilating the afferent arterioles and improves glomerular hypertension by dilating the efferent arterioles in hypertensive rats. [5] |
別名 | Iperten, Franidipine, Artedil |
分子量 | 610.7 |
分子式 | C35H38N4O6 |
CAS No. | 89226-50-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 113 mg/mL (185 mM)
Ethanol: 3 mg/mL (4.91 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. 詳細
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Manidipine 89226-50-6 Membrane transporter/Ion channel Metabolism Calcium Channel Inhibitor inhibit Ca channels Iperten Ca2+ channels Franidipine Artedil inhibitor