Powder: -20°C for 3 years | In solvent: -80°C for 1 year
McN5691 is a voltage sensitive calcium channel blocker.
In vivo | McN5691, a chemical compound studied for its antihypertensive properties, undergoes extensive metabolism in dogs, with negligible amounts remaining unchanged in urine (less than 0.1%) and feces (19%) within the first 24 and 48 hours, respectively, and 36% detectable in plasma after 4 hours. A comparative study on McN5691 (McN-5691) revealed that its vascular resistance effects are notably higher in spontaneously hypertensive rats (SHR) compared to Wistar-Kyoto rats (WKY), with significant differences observed in the cerebellum and midbrain. Further investigation into McN5691's (RWJ-26240) excretion and metabolism in beagle dogs highlighted that a predominant portion of a radioactive dose (96.8%) is excreted through feces, with only a minor fraction (2.8%) eliminated via urine within seven days following the oral administration of 14C-McN5691, corroborating that over 87% of the dose is expelled through feces within the first 48 hours. |
別名 | RWJ26240 |
分子量 | 457.6 |
分子式 | C30H35NO3 |
CAS No. | 99254-95-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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McN5691 99254-95-2 Membrane transporter/Ion channel Metabolism Calcium Channel RWJ-26240 RWJ 26240 McN 5691 RWJ26240 McN-5691 Inhibitor inhibitor inhibit