Powder: -20°C for 3 years | In solvent: -80°C for 1 year
8-Bromo-cGMP sodium is a PKG activator, a membrane-permeable analog of cGMP. 8-Bromo-cGMP sodium has pain-relieving and vasodilatory effects, significantly inhibits Ca2+ macroscopic currents, and inhibits high K+-stimulated insulin release.
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5 mg | 在庫あり | ¥ 13,000 | |||
10 mg | 在庫あり | ¥ 20,500 | |||
25 mg | 在庫あり | ¥ 41,000 | |||
50 mg | 在庫あり | お問い合わせ |
説明 | 8-Bromo-cGMP sodium is a PKG activator, a membrane-permeable analog of cGMP. 8-Bromo-cGMP sodium has pain-relieving and vasodilatory effects, significantly inhibits Ca2+ macroscopic currents, and inhibits high K+-stimulated insulin release. |
In vitro |
8-Bromo-cGMP sodium (1 µM-0.1 mM) can inhibit acetylcholine-induced increases in intracellular calcium concentrations.[1] 8-Bromo-cGMP sodium (1-100 μM; 16 h) induces the synthesis of HO-1 protein in a concentration-dependent fashion.[2] 8-Bromo-cGMP sodium (1-100 μM; 8 h) increases the resistance of LLC-PK1 cells to CsA toxicity in concentration-dependently.[2] |
In vivo |
8-Bromo-cGMP sodium (0.3, 1, 3 nM; intrathecal administration; 10 min before the test; male ICR mice) significantly increases the tail-flick latency in Vincristine-treated mice to the level observed in vehicle-treated naive mice in dose-dependently.[3] 8-Bromo-cGMP sodium (10 mg/kg; iv; single dose) results in vasodilator responses in WT littermates and eNOS-Tg mice in C57BL/6 background (19-35 g).[4] |
分子量 | 447.09 |
分子式 | C10H11BrN5NaO7P |
CAS No. | 51116-01-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 90.0 mg/mL (201.8 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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8-Bromo-cGMP sodium 51116-01-9 Membrane transporter/Ion channel Metabolism Tyrosine Kinase/Adaptors Calcium Channel PKA 8 Bromo cGMP sodium 8BromocGMP sodium Inhibitor inhibitor inhibit