store at low temperature,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide indirectly decreases osteoclast differentiation through a decreased RANKL/OPG ratio. Muramyl dipeptide directly increases osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways. Muramyl dipeptide is an inducer of bone formation through the induction of Runx2 .
説明 | Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide indirectly decreases osteoclast differentiation through a decreased RANKL/OPG ratio. Muramyl dipeptide directly increases osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways. Muramyl dipeptide is an inducer of bone formation through the induction of Runx2 . |
In vitro | Muramyl dipeptide increases the protein expression of Runx2 in a dose-dependent manner (0.1-10 μg/mL; 24 hours)[1]. It also enhances the mRNA levels of Runx2 in a dose-dependent manner (0.1-10 μg/mL; 6 hours)[2]. Muramyl dipeptide indirectly attenuates osteoclast differentiation by reducing the RANKL/OPG ratio[2]. |
In vivo |
Muramyl dipeptide can be used for animal modeling to establish sepsis models. Muramyl dipeptide (1.25 mg/kg; intraperitoneal injection; twice) alleviates osteoporosis-induced bone loss[2]. |
別名 | MDP |
分子量 | 492.48 |
分子式 | C19H32N4O11 |
CAS No. | 53678-77-6 |
store at low temperature,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (101.53 mM), Sonication is recommended.
H2O: 20 mg/mL (40.61 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Muramyl dipeptide 53678-77-6 Immunology/Inflammation NF-Κb NOD MDP Inhibitor inhibitor inhibit