Powder: -20°C for 3 years | In solvent: -80°C for 1 year
YQ128 is a potent and selective inhibitor of second-generation NLRP3 (NOD-like receptor P3) inflammasome(IC50 of 0.30 µM), with anti-inflammatory activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 12,000 | |||
5 mg | 在庫あり | ¥ 28,000 | |||
10 mg | 在庫あり | ¥ 45,500 | |||
25 mg | 在庫あり | ¥ 74,000 | |||
50 mg | 在庫あり | ¥ 123,500 | |||
100 mg | 在庫あり | ¥ 178,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 34,000 |
説明 | YQ128 is a potent and selective inhibitor of second-generation NLRP3 (NOD-like receptor P3) inflammasome(IC50 of 0.30 µM), with anti-inflammatory activity. |
ターゲット&IC50 | IL-1β:, NLRP3:0.30 μM |
In vitro | The release of IL-1β from peritoneal macrophages upon LPS/ATP challenge(IC50 of 1.59 μM) dose dependently suppressed by YQ128 (0.3-100 μM; 30 mins). |
In vivo | YQ128 (oral; 20 mg/kg) shows delayed gastrointestinal absorption with a tmax and cmax of 12 h and 73 ng/mL, respectively. YQ128 exhibits extensive extravascular distribution with a large steady-state volume of distribution (Vdss) of 8.5 L/kg and rapid total clearance (CLtot) of 41 mL/min/kg. In C57BL/6 mice, YQ128 (10 mg/kg) has been shown to trigger IL-1β production in a NLRP3- dependent manner . |
分子量 | 545.11 |
分子式 | C27H29ClN2O4S2 |
CAS No. | 2454246-18-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 248 mg/mL (454.95 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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YQ128 2454246-18-3 Immunology/Inflammation NF-Κb IL Receptor NOD-like Receptor (NLR) NOD Interleukin inhibit Inhibitor Interleukin Related YQ 128 YQ-128 inhibitor