Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NG,NG-dimethyl-L-Arginine dihydrochloride is an endogenous nitric oxide synthase inhibitor. Nitric oxide (NO) that is synthesised from L-arginine contributes to the regulation of blood pressure and to host defence[1].
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 10,000 | |||
10 mg | 在庫あり | お問い合わせ | |||
50 mg | 在庫あり | お問い合わせ | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 12,500 |
説明 | NG,NG-dimethyl-L-Arginine dihydrochloride is an endogenous nitric oxide synthase inhibitor. Nitric oxide (NO) that is synthesised from L-arginine contributes to the regulation of blood pressure and to host defence[1]. |
In vitro | NG,NG-dimethyl-L-Arginine (ADMA) was found to be able to inhibit macrophage and vascular NO synthase. When added to a cytosolic preparation of macrophage NO synthase, ADMA could cause dose-dependent inhibition of NO formation. In the presence of added arginine, ADMA could inhibited NO synthesis and the inhibitory effects of ADMA were prevented by addition of L-arginine so that the rate of NO synthesis did not significantly differ from control values [1]. |
In vivo | Animal study showed that the injection of 1-30 mg/kg ADMA into 3 anaesthetised guineapigs could cause dose-dependent increases in mean arterial blood pressure. Moreover, during continuous infusion of ADMA, which caused plasma ADMA concentrations to rise approximately 9-fold, the systolic blood pressure was raised by nearly 15 % [1]. |
分子量 | 275.18 |
分子式 | C8H20Cl2N4O2 |
CAS No. | 220805-22-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 11 mg/mL (39.97 mM)
DMSO: 7mg/mL (25.43 mM)
H2O: 14mg/mL (50.87 mM)
You can also refer to dose conversion for different animals. 詳細
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NG,NG-dimethyl-L-Arginine dihydrochloride 220805-22-1 Immunology/Inflammation NO Synthase NG,NG dimethyl L Arginine dihydrochloride NG,NG-dimethyl-L-Arginine Dihydrochloride NG,NG-dimethyl-L-Arginine NG,NGdimethylLArginine dihydrochloride Inhibitor inhibitor inhibit