Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NKP608 is a selective and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro(IC50: 2.6 nM) and in vivo.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
2 mg | 約 5 days | ¥ 35,000 |
5 mg | 約 5 days | ¥ 59,500 |
25 mg | 約8-10 週間 | ¥ 176,000 |
50 mg | 約8-10 週間 | ¥ 228,500 |
100 mg | 約8-10 週間 | ¥ 363,000 |
説明 | NKP608 is a selective and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro(IC50: 2.6 nM) and in vivo. |
ターゲット&IC50 | NK1 receptor:2.6 nM |
In vitro | The binding of NKP608 to the bovine retina was characterized by an IC50 of 2.6 nM, whereas the compound's affinity to other receptor binding sites, including NK-2 and NK-3, was much lower. Species differences in IC50 values with NKP608 were less pronounced than with previously described NK-1 receptor antagonists, being 13 and 27 nM in gerbil midbrain and rat striatum, respectively. |
In vivo | Using the hindfoot thumping model in gerbils, NKP608 exhibited a potent NK-1 antagonistic activity following oral administration (ID50: 0.23 mg/kg, 2 h pretreatment), supporting a central activity of NKP608. |
分子量 | 619.98 |
分子式 | C31H24ClF6N3O2 |
CAS No. | 177707-12-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Insoluble
DMSO: 100 mg/mL (161.30 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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NKP608 177707-12-9 GPCR/G Protein Neuroscience Neurokinin receptor NKP 608 NKP-608 Inhibitor inhibitor inhibit