Powder: -20°C for 3 years | In solvent: -80°C for 1 year
L-732138 is a potent and competitive antagonist of neurokinin-1 (NK-1) receptor(IC50 : 2.3 nM)
説明 | L-732138 is a potent and competitive antagonist of neurokinin-1 (NK-1) receptor(IC50 : 2.3 nM) |
ターゲット&IC50 | NK1:2.3 nM |
In vitro | L-732,138 against three human melanoma cell lines (COLO 858, MEL HO, COLO 679).?L-732,138 elicits cell growth inhibition in a concentration dependent manner in the melanoma cells studied.?Moreover, L-732,138 blocks SP mitogen stimulation.?The specific antitumor action of L-732,138 occurred through the NK-1 receptor and melanoma cell death was by apoptosis[1]. |
In vivo | L-732138?Abolished the vagally-induced plasma leakage in tracheobronchial tissues, and dose-dependently inhibited the LPS enhanced vagally-induced plasma exudation in traceobronchial tissues[2]. |
細胞研究 | Cell Line:COLO 858, MEL HO and COLO 679 cells. Concentration:0 μM, 20 μM, 40 μM, 60 μM, 80 μM, 100 μM. Incubation Time:First doubling time[1]. |
動物実験 | Animal Model:Male Dunkin-Hartley guinea-pigs (350-500 g) injected with lipopolysaccharide (LPS)[3].Dosage:10-4 mol/kg ,10-3 mol/kg and 10-2 mol/kg. Administration:Intravenous injection; for 15 minutes[2] |
分子量 | 472.38 |
分子式 | C22H18F6N2O3 |
CAS No. | 148451-96-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.72 mg/mL (10 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
L-732138 148451-96-1 GPCR/G Protein Neuroscience Neurokinin receptor cytotoxicity vagally-induced NK receptor Neurokinin Receptor Inhibitor ntravenously lipopolysaccharide plasma Tachykinin receptor stimulation L 732138 mitogen peralgesia inhibit Antitumorhy L732138 apoptotic inhibitor