Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NMS-P118 is a potent, selective and orally available Inhibitor of PARP-1 for cancer therapy.
説明 | NMS-P118 is a potent, selective and orally available Inhibitor of PARP-1 for cancer therapy. |
ターゲット&IC50 | PARP2:1390 nM (Kd), PARP1:9 nM (Kd) |
In vitro | NMS-P118 proved to be a potent, orally available, and highly selective PARP-1 inhibitor endowed with excellent ADME and pharmacokinetic profiles and high efficacy in vivo both as a single agent and in combination with Temozolomide in MDA-MB-436 and Capan-1 xenograft models, respectively. Cocrystal structures of 20by with both PARP-1 and PARP-2 catalytic domain proteins allowed rationalization of the observed selectivity. |
分子量 | 395.42 |
分子式 | C20H24F3N3O2 |
CAS No. | 1262417-51-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 16 mg/mL (40.46 mM), Sonication and heating are recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
NMS-P118 1262417-51-5 Chromatin/Epigenetic DNA Damage/DNA Repair PARP inhibit NMS P118 NMS-P-118 NMSP118 Inhibitor poly ADP ribose polymerase NMS-P 118 inhibitor