Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NPS-2143 (SB 262470A) is a novel potent and selective antagonist of Ca(2+) receptor.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 11,000 | |||
10 mg | 在庫あり | ¥ 18,500 | |||
25 mg | 在庫あり | ¥ 36,000 | |||
50 mg | 在庫あり | ¥ 53,500 | |||
100 mg | 在庫あり | ¥ 80,000 |
ターゲット&IC50 | Ca2+ receptor:43 nM |
In vitro | NPS 2143 stimulates the secretion of parathyroid hormone (PTH) from bovine parathyroid cells with an effective concentration (EC50) of 41 nM. Moreover, NPS 2143 inhibits the suppressive effect of the calcimimetic NPS R-467 on PTH secretion from bovine parathyroid cells and the inhibition of cAMP formation stimulated by isoproterenol in the presence of extracellular Ca2+. In HEK 293 cells expressing the human Ca2+ receptor, NPS 2143 blocks the increase in cytosolic Ca2+ concentration induced by receptor activation, with an inhibitory concentration (IC50) of 43 nM. Furthermore, in HEK-293 cells transiently expressing hCaSRs, NPS 2143 significantly inhibits the umami taste perception by effectively suppressing GSH (data not shown) and γ-Glu-Val-Gly activity. |
In vivo | In normotensive rats, intravenous administration of NPS 2143 (1 mg/kg) significantly increased mean arterial pressure (MAP) in the presence of the parathyroid gland. Additionally, NPS 2143 induced a rapid 4-5 fold increase in plasma parathyroid hormone (PTH) levels and an instantaneous rise in plasma calcium (Ca2+) levels. |
別名 | SB262470, NPS 2143, SB 262470A |
分子量 | 408.92 |
分子式 | C24H25ClN2O2 |
CAS No. | 284035-33-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: <1 mg/mL (2.45 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
NPS-2143 284035-33-2 GPCR/G Protein Membrane transporter/Ion channel Metabolism CaSR Calcium Channel SB-262470A Inhibitor inhibit Calcium-sensing receptor SB262470 NPS 2143 SB 262470 SB 262470A NPS2143 SB-262470 inhibitor