Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NSC-65809 (Raphin1) is a selective inhibitor of R15B.
説明 | NSC-65809 (Raphin1) is a selective inhibitor of R15B. |
In vitro | In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis. In vitro, Raphin1 inhibits the recombinant R15B-PP1c holoenzyme, but not the closely related R15A-PP1c, by interfering with substrate recruitment |
In vivo | Raphin1 was orally bioavailable, crossed the blood-brain barrier, and demonstrated efficacy in a mouse model of Huntington's disease. |
別名 | 3-[(2,3-dichlorophenyl)methylene]carbazamidine, Raphin1 |
分子量 | 231.08 |
分子式 | C8H8Cl2N4 |
CAS No. | 94023-67-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 35 mg/mL (151.46 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
NSC 65809 94023-67-3 Metabolism Phosphatase NSC-65809 3-[(2,3-dichlorophenyl)methylene]carbazamidine NSC65809 Raphin1 Inhibitor inhibitor inhibit