Powder: -20°C for 3 years | In solvent: -80°C for 1 year
OATD-01 is a highly active inhibitor of both Chitotriosidase (CHIT1) and acidic mammalian chitinase (AMCase).
説明 | OATD-01 is a highly active inhibitor of both Chitotriosidase (CHIT1) and acidic mammalian chitinase (AMCase). |
ターゲット&IC50 | AMCase (mouse):7.8 nM, CIT1 (human):23 nM, AMCase (human):9 nM, Chitinase 1 (mouse):28 nM |
In vitro | The Ki values for hCHIT1,mCHIT1, hAMCase and mAMCase are 17.3 nM, 26.05 nM, 4.8 nM and 5.7 nM, respectively[1]. These Ki values reveals good correlation with earlier established IC50 data, which are 23 nM, 28 nM, 9 nM and 7.8 nM, respectively[1]. OATD-01 shows excellect PK profile in multiple species and is selectivity against a panel of other off-targets[1]. |
In vivo | OATD-01 given orally once daily in a range of doses between 30 and 100 mg/kg showed significant antifibrotic efficacy in an animal model of bleomycin-induced pulmonary fibrosis[1]. |
分子量 | 390.91 |
分子式 | C19H27ClN6O |
CAS No. | 2088453-21-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 85 mg/ml (217.44 mM)
You can also refer to dose conversion for different animals. 詳細
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OATD-01 2088453-21-6 Others inhibit OATD 01 CHIT1 chitinase antifibrotic IPF pulmonary fibrosis OATD01 Inhibitor inhibitor