|
T9592 |
OATD-01
|
|
Others
|
|
OATD-01 is a highly active inhibitor of both Chitotriosidase (CHIT1) and acidic mammalian chitinase (AMCase). |
|
T7436 |
Cilofexor
|
|
FXR
,
Autophagy
|
|
Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist. |
|
T28578 |
Ro24-7429
|
Ro 24-7429,Ro-24-7429,Ro 247429 |
HIV Protease
|
|
Ro24-7429 is an effective and orally active antagonist of HIV-1 transactivator protein Tat and an inhibitor of a runt-related transcription factor 1. Ro24-7429 has anti-HIV, antifibrotic, and anti-inflammatory effects. |
|
T13473 |
αvβ1 integrin-IN-1
|
|
Integrin
|
|
αvβ1 integrin-IN-1 is a potent and selective inhibitor of αvβ1 integrin (IC50 of 0.63 nM) with antifibrotic effects. |
|
T9947 |
GW-6604
|
|
PAI-1
,
ALK
,
TGF-beta/Smad
|
|
GW-6604 is an ALK5 inhibitor and shows clear antifibrotic effects resulting in liver function improvement. |
|
T67773 |
IMSs inhibitor S12 Perchlorate
|
|
Others
|
|
IMSs inhibitor S12 Perchlorate has antifibrotic and anticancer properties. |
|
T14895 |
Tanzisertib
|
CC-930 |
JNK
|
|
Tanzisertib (CC-930) (CC-930) is a potent inhibitor of JNK1/2/3 with IC50s of 61/7/6 nM, respectively, with potential antifibrotic activity. |
|
T60162 |
1H-Pyrazole-5-carboxamide, 4-(5-chloro-2-furanyl)-1,3-bis(2,4-difluorophenyl)-4,5-dihydro-5-methyl-N-[(4-methyl-2-morpholinyl)methyl]
|
|
Others
|
|
1H-Pyrazole-5-carboxamide, 4-(5-chloro-2-furanyl)-1,3-bis(2,4-difluorophenyl)-4,5-dihydro-5-methyl-N-[(4-methyl-2-morpholinyl)methyl] is an antifibrotic agent. |
|
T76856 |
Andecaliximab
|
GS-5745 |
MMP
,
Virus Protease
|
|
Andecaliximab is a recombinant IgG4 monoclonal antibody targeting matrix metalloproteinase 9 (MMP9). Andecaliximab showed antifibrotic effects in a mouse model of idiopathic pulmonary fibrosis. Andecaliximab can be used ... |
|
T39933 |
Bexotegrast
|
PLN-74809 |
Integrin
|
|
Bexotegrast (PLN-74809) is an orally active and potent inhibitor of αvβ6 and αvβ1 integrins with antifibrotic effects, inhibits αvβ6 and αvβ1-induced activation of TGF-β, and can be used for the study of idiopathic pulmo... |
|
T15300 |
Fluorofenidone
|
AKF-PD |
Others
|
|
Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway. Fluorofenidone is an an... |
|
T62882 |
Ezurpimtrostat hydrochloride
|
GNS561 hydrochloride |
Antiviral
|
|
Ezurpimtrostat hydrochloride (GNS561 hydrochloride) is an orally available palmitoyl protein thioesterase-1 inhibitor with antifibrotic, antiviral, and anticancer effects that blocks cancer cell proliferation by interact... |
|
T67961 |
Safironil
|
|
Others
|
|
safironil is a novel antifibrotic compound and a competitive inhibitor of collagen synthesis. safironil inhibited in vitro experiments on fibroblast activation monitored by collagen I mRNA or smooth muscle alpha-actin le... |
|
T40943 |
EMD527040
|
|
|
|
EMD527040 is a powerful and highly specific αvβ6 antagonist, exhibiting notable antifibrotic properties. It is suitable for conducting research on carcinoma and liver fibrosis. |
|
T39739 |
Bersiporocin
|
|
|
|
Bersiporocin, a prolyl-tRNA synthetase inhibitor, demonstrates potent activity with an IC50 of ≤100 nM against phosphoribosylpyrophosphate synthetase (PRS). This compound proves valuable for antifibrotic research. |
|
T10862 |
Collagen proline hydroxylase inhibitor
|
|
Others
|
|
Collagen proline hydroxylase inhibitor is an inhibitor collagen proline hydroxylase and useful for antifibrotic proliferative agents. |
|
T10471 |
BAY 60-2770
|
|
Others
|
|
BAY 60-2770 is a selective and orally active soluble guanylyl cyclase (sGC) activator with antifibrotic effect. It increases the activity of sGC in a nitric oxide-independent manner. |
|
T68431 |
CCG-58150
|
|
|
|
CCG-58150 is a potentiInhibitor of Rho/Myocardin-Related Transcription Factor (MRTF)/Serum Response Factor (SRF)-Mediated Gene Transcription
as Potential Antifibrotic Agents for Scleroderma. |
|
T12485 |
Pirfenidone-d5
|
AMR69 D5,Pirfenidone D5 |
Others
|
|
Pirfenidone D5 is a deuterium labeled Pirfenidone. Pirfenidone is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. |
|
T81300 |
Relaxin H3 (human)
|
|
|
|
Relaxin H3 (human) is a relaxin peptide that exhibits antifibrotic effects through activation of RXFP1 [1]. |
|
T73625 |
αvβ1 integrin-IN-1 TFA
|
|
|
|
αvβ1 Integrin-IN-1 TFA (Compound C8) is a potent, selective inhibitor of αvβ1 integrin, demonstrating an IC 50 value of 0.63 nM. It exhibits antifibrotic effects [1]. |
|
T82165 |
HTH-02-006
|
|
AMPK
|
|
HTH-02-006, a NUAK2 inhibitor (IC50 = 126 nM), decreases phosphorylated MYPT1 levels in HuCCT-1 cells and inhibits YAP-driven cell proliferation, hepatomegaly, and tumorigenesis. Additionally, it possesses an antifibroti... |
|
T75752 |
N-Acetyl-Ser-Asp-Lys-Pro acetate
|
|
|
|
N-Acetyl-Ser-Asp-Lys-Pro (Ac-SDKP) acetate, a specific substrate for the N-terminal active site of angiotensin-converting enzyme (ACE), functions as a natural inhibitor of pluripotent hematopoietic stem cell proliferatio... |
|
T74782 |
CXJ-2
|
|
PI3K
|
|
CXJ-2, a cyclic peptide, demonstrates moderate affinity for elastin-derived peptides (EDPs) and exhibits potent inhibition of the PI3K/ERK pathway, alongside significant reduction in hepatic stellate cell proliferation a... |
|
T63809 |
Ansornitinib
|
|
|
|
Ansornitinib is an oral, active dual kinase inhibitor that inhibits platelet-derived growth factor receptor (PDGFR) and vascular endothelial growth factor receptor (VEGFR2).Ansornitinib is an antifibrotic agent that can ... |
|
T41150 |
EMD 527040 hydrochloride
|
|
|
|
EMD 527040 hydrochloride is an effective integrin αVβ6 inhibitor. The IC 50 values of EMD 527040 hydrochloride were 6 nM and 1.6 μM to inhibit αVβ6 binding to fibronectin and αVβ6 expression cells to fibronectin, respect... |
|
T73414 |
EDP-305
|
|
|
|
EDP-305, an orally active, potent, and selective agonist of the farnesoid X receptor (FXR), exhibits EC50 values of 34 nM in chimeric FXR within CHO cells and 8 nM in full-length FXR in HEK cells. Demonstrating a potent ... |
|
T63776 |
PDE1-IN-4
|
|
|
|
PDE1-IN-4 is a potent and selective inhibitor of PDE1 (phosphodiesterase-1), acting on PDE1C (IC50: 10 nM), PDE1A (IC50: 145 nM) and PDE1B (IC50: 354 nM). PDE1-IN-4 regulates cAMP (3′,5′-cyclic adenosine monophosphate) a... |
