Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ORM-10921 is an α2C-adrenoceptor antagonist that has shown antipsychotic and antidepressant activity in animal studies.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 91,500 |
5 mg | 在庫あり | ¥ 223,000 |
10 mg | 在庫あり | ¥ 296,000 |
25 mg | 在庫あり | ¥ 447,500 |
50 mg | 在庫あり | ¥ 601,500 |
説明 | ORM-10921 is an α2C-adrenoceptor antagonist that has shown antipsychotic and antidepressant activity in animal studies. |
In vivo | The role of the α2C-AR in modulating two key depression-related behaviors in the Flinders Sensitive Line (FSL) rat was studied using a dose-response analysis following subcutaneous administration with the selective α2C-AR antagonist ORM-10921 (0.03, 0.3 mg/kg), the nonselective α2-AR antagonist idazoxan (3 mg/kg), or vehicle once daily for 14 days. Behavior in the novel object recognition test forced swim test (FST), and locomotor activity test was assessed. ORM-10921 at both doses but not idazoxan significantly reversed immobility in the FST as well as attenuated cognitive deficits in FSL animals.[3] |
別名 | ORM10921, ORM 10921 |
分子量 | 285.38 |
分子式 | C18H23NO2 |
CAS No. | 610782-82-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (157.68 mM)
You can also refer to dose conversion for different animals. 詳細
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ORM-10921 610782-82-6 GPCR/G Protein Neuroscience Adrenergic Receptor ORM10921 ORM 10921 Inhibitor inhibitor inhibit