Powder: -20°C for 3 years | In solvent: -80°C for 1 year
OSBPL7-IN-1 is an orally active inhibitor of oxysterol binding protein like 7 (OSBPL7). OSBPL7-IN-1 promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression[1].
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 18,500 | |||
5 mg | 在庫あり | ¥ 45,500 | |||
10 mg | 在庫あり | ¥ 72,000 | |||
25 mg | 在庫あり | ¥ 118,000 | |||
50 mg | 在庫あり | ¥ 158,500 | |||
100 mg | 在庫あり | ¥ 209,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 45,000 |
説明 | OSBPL7-IN-1 is an orally active inhibitor of oxysterol binding protein like 7 (OSBPL7). OSBPL7-IN-1 promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression[1]. |
In vitro | OSBPL7-IN-1 (compound G; 1-10?μM) increase plasma membrane ATP-binding cassette transporter (ABCA1) in cultured human podocytes, and significantly increase ABCA1-dependent cholesterol efflux[1]. |
In vivo | OSBPL7-IN-1 (100?mg/kg; oral gavage; daily; for 28 days) treatment normalizes proteinuria, and prevents renal function decline in mouse models of proteinuric kidney disease[1]. |
分子量 | 463.28 |
分子式 | C20H19Cl2F3N2O3 |
CAS No. | 1269826-44-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11 mg/mL (23.74 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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OSBPL7-IN-1 1269826-44-9 Others OSBPL7 orally active ABCA1 OSBPL7 IN 1 Inhibitor OSBPL-7-IN-1 OSBPL7IN1 inhibit inhibitor