検索結果

Search Results for " ABCA1 "

ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T9565	OSBPL7-IN-1		Others
	OSBPL7-IN-1 is an orally active inhibitor of oxysterol binding protein like 7 (OSBPL7). OSBPL7-IN-1 promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression[1].		Others
T27478	GSK3987		Liver X Receptor
	GSK3987 is an LXR ligand. GSK3987 recruits the steroid receptor coactivator-1 to human LXRalpha and LXRbeta with EC50s of 40 nM.		Liver X Receptor
T9010	IMM-H007		Others , AMPK
	IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression		Others , AMPK
T18975	DIDS sodium salt	MDL101114ZA	VDAC , ABC
	DIDS sodium salt (MDL101114ZA) is a dual inhibitor of ABCA1 and VDAC1.		VDAC , ABC
T9106	E1231		Sirtuin
	E1231 is an activator of SIRT1 . E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.		Sirtuin
T68668	AZ-1
	AZ-1 is an inducer of ABCA1 and apoE. It enhances ABCA1 activity and decreases P2X7 receptor activity. AZ-1 activates endogenous LXR signaling but shows no direct LXRα or LXRβ agonist activity.
T29428	4010B-30	4010B30
	4010B-30 is an up-regulation of apolipoprotein A-I gene expression. It functions by promoting cholesterol efflux, ABCA1 expression, and PPAR activation.
T68696	AZ-2
	AZ-2 is an inducer of ABCA1 and apoE. It enhances ABCA1 activity and decreases P2X7 receptor activity. AZ-2 activates endogenous LXR signaling but shows no direct LXRα or LXRβ agonist activity.
T25528	IMB-808
	IMB-808 is an effective partial dual agonist of liver X receptor α and β (LXRα/β) that promotes the expression of genes related to reverse cholesterol transport (including ABCA1 and ABCG1).
T25356	E17110	E-17110,E 17110
	E17110 is an LXRβ agonist. E17110 exhibited a significant activation effect on LXRβ (EC50: 0.72 μmol/L). E17110 also increased the expression of ABCA1 and ABCG1 in RAW264.7 macrophages. E17110 significantly decreased cel...
T35927	C2 L-threo Ceramide (d18:1/2:0)	C2 L-threo Ceramide (d18:1/2:0)
	C2 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor when used at a concentration o...
T83683	St-Ht31 ammonium	sHt31
	st-Ht31, a cell-permeable stearated peptide derived from the amphipathic helix domain of A-kinase anchoring proteins (AKAPs), effectively binds protein kinase A (PKA), impacting PKA's cellular interactions without alteri...

Compounds

Target: Liver X Receptor

Synonym: E-17110,E 17110

Target:

C2 L-threo Ceramide (d18:1/2:0)

T35927

Synonym: C2 L-threo Ceramide (d18:1/2:0)

カタログ番号	製品名	別名	ターゲット
T5S0246	Pseudoprotodioscin		Others , Fatty Acid Synthase
	1. Pseudoprotodioscin has moderate cytotoxicity.		Others , Fatty Acid Synthase
T8165	Erythrodiol		Endogenous Metabolite , ABC
	Erythrodiol, an olive oil component, promotes Cholesterol efflux (ChE) by selectively inhibiting the degradation of ABCA1 protein.		Endogenous Metabolite , ABC
TN1804	Isosilybin A		Apoptosis , Tyrosinase , PPAR , ABC
	Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (IC50=12.1-44.9μM) of tyrosinase. Isosilybin A shows anti-angio...		Apoptosis , Tyrosinase , PPAR , ABC
T72961	Falcarindiol	法卡林二醇
	Falcarindiol, an orally active polyacetylenic oxylipin, not only activates PPARγ, enhancing ABCA1 expression—a cholesterol transporter—but also induces apoptosis and autophagy. This compound exhibits anti-inflammatory, a...
TN5097	Tanshindiol C		LDL , Histone Methyltransferase
	Tanshindiol C protects macrophages from oxLDL induced foam cell formation via activation of Prdx1/ABCA1 signaling and that Prdx1 may be a novel target for therapeutic intervention of atherosclerosis.It possesses a unique...		LDL , Histone Methyltransferase
TN1462	Cajanin		ERK , MEK , Akt
	Cajanin has potential hypolipidemic effects,possibly via up-regulating the ABCA1 protein expression,subsequently resulting in increased macrophage cholesterol efflux and RCT, it can significantly improve basal glucose up...		ERK , MEK , Akt

天然物製品

Pseudoprotodioscin

T5S0246

Synonym:

Target: Others, Fatty Acid Synthase

Erythrodiol

T8165

Synonym:

Target: Endogenous Metabolite, ABC

Isosilybin A

TN1804

Synonym:

Target: Apoptosis, Tyrosinase, PPAR, ABC

Target: LDL, Histone Methyltransferase

Cajanin

TN1462

Synonym:

Target: ERK, MEK, Akt

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPK-01291	ANXA1 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	E. coli
	Atherosclerosis, characterized by the formation of fat-laden plaques, is a chronic inflammatory disease. ABCA1 promotes cholesterol efflux, reduces cellular cholesterol accumulation, and regulates anti-inflammatory activ...
TMPK-00799	ANXA1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Atherosclerosis, characterized by the formation of fat-laden plaques, is a chronic inflammatory disease. ABCA1 promotes cholesterol efflux, reduces cellular cholesterol accumulation, and regulates anti-inflammatory activ...
TMPK-00768	ANXA1 Protein, Human, Recombinant (His)	Human	E. coli
	Atherosclerosis, characterized by the formation of fat-laden plaques, is a chronic inflammatory disease. ABCA1 promotes cholesterol efflux, reduces cellular cholesterol accumulation, and regulates anti-inflammatory activ...

ANXA1 Protein, Cynomolgus, Recombinant (His)

TMPK-01291

Species: Cynomolgus

Expression System: E. coli

ANXA1 Protein, Mouse, Recombinant (His)

TMPK-00799

Species: Mouse

Expression System: E. coli

ANXA1 Protein, Human, Recombinant (His)

TMPK-00768

Species: Human

Expression System: E. coli