Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Org-26576 is a positive allosteric modulator of the AMPA receptor.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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2 mg | 在庫あり | ¥ 9,500 | |||
5 mg | 在庫あり | ¥ 15,500 | |||
10 mg | 在庫あり | ¥ 24,500 | |||
25 mg | 在庫あり | ¥ 41,000 | |||
50 mg | 在庫あり | ¥ 59,000 | |||
100 mg | 在庫あり | ¥ 103,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 16,500 |
説明 | Org-26576 is a positive allosteric modulator of the AMPA receptor. |
In vitro | Org-26576 shows selectivity for AMPA receptors when tested at 10 μM against >60 molecular targets including G-Protein Coupled Receptors, ion channels, and kinases. Org-26576 represents structurally a distinct chemical series derived from the first generation ampakine CX516 and shows 10-30 fold greater potency when compared to CX516 in potentiating AMPA-mediated electrophysiological responses with an EC50 of 8-16 μM in rat hippocampal primary cultured neurons [1]. |
In vivo | Org-26576 (Chronic administration) increases progenitor cell proliferation in the dentate gyrus (approximately 40%) and in the prelimbic cortex (approximately 35%) at the 10-mg/kg dosage. Cells born in response to chronic Org-26576 in dentate gyrus show increased rates of survival (approximately 30%) with the majority of surviving cells expressing a neuronal phenotype. Org-26576 (1 mg/kg) produces obviously enhances the anteroventral and laterodorsal thalamus, cingulate cortex, dentate gyrus, and CA3 subfield of the hippocampus in mice. AMPA receptor potentiation by Org-26576 exerts a positive modulatory influence on brain-derived neurotrophic factor (BDNF) expression during ongoing neuronal activity. Total BDNF mRNA levels are significantly increased in the hippocampus of animals exposed to the combination of Org-26576 and stress[1][2][3]. |
分子量 | 204.23 |
分子式 | C11H12N2O2 |
CAS No. | 1026791-61-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (122.41 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Org-26576 1026791-61-6 Membrane transporter/Ion channel Neuroscience iGluR GluR inhibit Inhibitor Org 26576 Ionotropic glutamate receptors Org26576 inhibitor