Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PEAQX tetrasodium hydrate (PEAQX tetrasodium hydrate (459836-30-7 free base)) is an orally available NMDA antagonist that is potent and selective. The IC50 value of PEAQX tetrasodium hydrate (459836-30-7 free base) against hNMDAR 1A/2A was 270 nM and 29600 nM against hNMDAR 1A/2B, respectively.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 16,500 | |||
5 mg | 在庫あり | ¥ 38,500 | |||
10 mg | 在庫あり | ¥ 57,500 | |||
25 mg | 在庫あり | ¥ 99,000 | |||
50 mg | 在庫あり | ¥ 146,000 |
説明 | PEAQX tetrasodium hydrate (PEAQX tetrasodium hydrate (459836-30-7 free base)) is an orally available NMDA antagonist that is potent and selective. The IC50 value of PEAQX tetrasodium hydrate (459836-30-7 free base) against hNMDAR 1A/2A was 270 nM and 29600 nM against hNMDAR 1A/2B, respectively. |
ターゲット&IC50 | NMDAR 1A/2B (human):29600 nM, NMDAR 1A/2A (human):270 nM |
In vitro | PEAQX has a high binding affinity for NMDA receptors (IC50=8 nM), and a functional preference in excess of 100-fold for hNMDA 1A/2A (IC50=of 270 nM) over 1A/2B receptors (IC50=29,600 nM).[1] |
In vivo |
PEAQX is practically inactive in Xenopus oocytes expressing hNMDA 1A/2B receptors, displays an ED50 value of 23 mg/kg in the MES test [1]. Sprague-Dawley rats were treated on PN7, PN9, and PN11 with PCP (10 mg/kg), PEAQX (NR2A-preferring antagonist; 10, 20, or 40 mg/kg), or ifenprodil (selective NR2B antagonist; 1, 5, or 10 mg/kg) and sacrificed for measurement of caspase-3 activity (an index of apoptosis) or allowed to age and tested for locomotor sensitization to PCP challenge on PN28-PN35. PCP or PEAQX on PN7, PN9, and PN11 markedly elevated caspase-3 activity in the cortex; ifenprodil showed no effect. Striatal apoptosis was evident only after subchronic treatment with a high dose of PEAQX (20 mg/kg). Animals treated with PCP or PEAQX on PN7, PN9, and PN11 showed a sensitized locomotor response to the PCP challenge on PN28-PN35.[2] |
別名 | NVP-AAM077 tetrasodium hydrate, PEAQX tetrasodium hydrate (459836-30-7 free base), PEAQX tetrasodium hydrate |
分子量 | 560.15 |
分子式 | C17H15BrN3Na4O6P |
CAS No. | T16451 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 22.9 mg/mL (41.0 mM), Sonication and heating are recommended.
You can also refer to dose conversion for different animals. 詳細
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PEAQX tetrasodium hydrate T16451 Apoptosis Membrane transporter/Ion channel Neuroscience NMDAR iGluR NVP-AAM077 tetrasodium hydrate PEAQX tetrasodium hydrate (459836-30-7 free base) 459836-30-7 free base 459836-30-7 NVP-AAM077 tetrasodium Hydrate PEAQX tetrasodium Hydrate Inhibitor inhibitor inhibit