Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PFM01 is an inhibitor of MRE11 endonuclease. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 9,000 | |||
10 mg | 在庫あり | ¥ 15,000 | |||
25 mg | 在庫あり | ¥ 28,500 | |||
50 mg | 在庫あり | ¥ 52,500 | |||
100 mg | 在庫あり | ¥ 85,500 | |||
200 mg | 在庫あり | ¥ 119,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 10,000 |
説明 | PFM01 is an inhibitor of MRE11 endonuclease. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR). |
In vitro |
PFM01 (100 μM) treatment allows normal DSB repair in HR-defective ATMi-treated or HSC62 (BRCA2-defective) cells[1]. RAD51 foci did not form following exo- or endo-inhibitor treatment (mirin or PFM01) in 1BR3 (WT) and HSC62 (BRCA2-defective) cells[1]. PFM01 (100 μM) enhances non-homologous end-joining (NHEJ) in H1299 dA3 cells and reduces homologous recombination (HR) in U2OS DR-GFP cells[1]. PFM01 substantially relieves the double-strand break (DSB) repair defect confers by mirin or PFM39 in irradiated G2 cells[1]. |
分子量 | 293.4 |
分子式 | C14H15NO2S2 |
CAS No. | 1558598-41-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4 mg/mL (13.63 mM)
You can also refer to dose conversion for different animals. 詳細
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PFM01 1558598-41-6 Others Inhibitor derivative MRE11 NHEJ Mirin DSB endonuclease PFM 01 N-alkylated PFM-01 inhibit inhibitor