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T8880 |
PFM01
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Others
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PFM01 is an inhibitor of MRE11 endonuclease. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR). |
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T4470 |
Pyridostatin TFA
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|
DNA/RNA Synthesis
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Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2. |
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T9760 |
IC 86621
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DNA-PK
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IC 86621 is a selective and reversible ATP-competitive inhibitor of DNA-PK with an IC50 of 120 nM. IC 86621 increases DNA double-strand break(DSB)-induced antitumor activity with an EC50 of 68 µM for DNA-PK mediated cell... |
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T9168 |
NSC 617145
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NSC617145,NSC-617145 |
DNA/RNA Synthesis
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NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner. |
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T1899 |
Pyridostatin
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RR82,Pyridostatin Trifluoroacetate Salt |
DNA/RNA Synthesis
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Pyridostatin (RR82) is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome or the telomeres. |
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T66152 |
NDSB-211
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Others
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NDSB-211 is a surfactant with small hydrophobic ends and mildly solubilizes proteins for protein extraction and analysis. |
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T8587 |
EcDsbB-IN-12
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4,5-dichloro-2-[(2-chlorophenyl)methyl]pyridazin-3-one |
Others
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EcDsbB-IN-12 (4,5-dichloro-2-[(2-chlorophenyl)methyl]pyridazin-3-one) targets disulfide bond forming enzyme,and is a novel potent specific inhibitor of EcDsbB. |
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T19925 |
EcDsbB-IN-9
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Others
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EcDsbB-IN-9 is a specific EcDsbB inhibitor, targeting disulfide bond forming enzyme DsbB of Gram-negative bacteria. |
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TF0120 |
NDSB-201
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|
|
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NDSB-201 is a useful organic compound for research related to life sciences. The catalog number is TF0120 and the CAS number is 15471-17-7. |
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TF0078 |
NDSB-195
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|
|
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NDSB-195 is a useful organic compound for research related to life sciences. The catalog number is TF0078 and the CAS number is 160255-06-1. |
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TF0032 |
NDSB-256
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|
|
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NDSB-256 is a useful organic compound for research related to life sciences. The catalog number is TF0032 and the CAS number is 81239-45-4. |
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TF0121 |
NDSB-221
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|
|
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NDSB-221 is a useful organic compound for research related to life sciences. The catalog number is TF0121 and the CAS number is 160788-56-7. |
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T8637 |
DMNB
|
6-Nitroveratraldehyde |
DNA-PK
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DMNB (6-Nitroveratraldehyde) is DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 of 15 μM, an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human c... |
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T0987 |
Gimeracil
|
Gimestat |
Autophagy
|
|
Gimeracil (Gimestat) is a competitive, reversible inhibitor of dihydropyrimidine dehydrogenase. |
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T63228 |
Simmiparib
|
SMOCL-9112 |
Apoptosis
,
PARP
|
|
Simmiparib (SMOCL-9112) is a novel and potent PARP1 and PARP2 inhibitor, a derivative of Olaparib.Simmiparib induces DNA double-strand breaks (DSBs) and cell cycle arrest in homologous recombination repair (HR)-deficient... |
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T68895 |
CBP-93872
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|
|
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CBP-93872 is a G2 checkpoint inhibitor. CBP-93872 specifically abrogates the DNA double-stranded break (DSB)-induced G2 checkpoint through inhibiting maintenance. CBP-93872 is an inhibitor of maintenance of the DSB-speci... |
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T68985 |
Amonafide L-malate
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|
|
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Amonafide L-malate is the malate salt of amonafide, an imide derivative of naphthalic acid, with potential antineoplastic activity. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in DNA double-s... |
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T74501 |
NHEJ inhibitor-1
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|
|
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NHEJ Inhibitor-1 (Compound C2), a trifunctional Pt(II) complex, mitigates non-homologous end joining (NHEJ)/homologous recombination (HR)-related double strand break (DSB) repairs, combating Cisplatin resistance in non-s... |
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T61017 |
Topoisomerase II inhibitor 6
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|
|
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Topoisomerase II inhibitor 6 (Compound 5) is a tryptanthrin derivative. Topoisomerase II inhibitor 6 is a potent and selective topoisomerase II inhibitor. Topoisomerase II inhibitor 6 blocks the CCRF-CEM cell cycle in th... |
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T78747 |
DiPT-4
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|
Topoisomerase
|
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DiPT-4, a dual TOP1/PARP1 inhibitor, effectively induces DNA double-strand breaks (DSBs), cell cycle arrest, and apoptosis in cancer cells, with potential to circumvent drug resistance [1]. |
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T80899 |
UNC3474
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|
|
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UNC3474, a small molecule ligand, selectively interacts with the aromatic methyl-lysine binding cage of the tumor protein 53BP1 Tudor domain (TT), exhibiting a dissociation constant (Kd) of 1.0±0.3 μM. It impedes 53BP1's... |
