Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PQCA is a muscarinic M1 receptor-positive allosteric regulator, which is highly selective and effective. PQCA exhibited EC50 values of 49 nM in rhesus monkey and 135 nM in human M1 receptors, but showed no activity against other muscarinic receptors. PQCA is a potential compound for reducing cognitive deficits associated with Alzheimer's disease.
説明 | PQCA is a muscarinic M1 receptor-positive allosteric regulator, which is highly selective and effective. PQCA exhibited EC50 values of 49 nM in rhesus monkey and 135 nM in human M1 receptors, but showed no activity against other muscarinic receptors. PQCA is a potential compound for reducing cognitive deficits associated with Alzheimer's disease. |
ターゲット&IC50 | M1 receptor (rhesus):49 nM (EC50), M1 receptor (human):135 nM (EC50), M1 receptor (human):135 nM (EC50), M1 receptor (rhesus):49 nM (EC50) |
In vivo | In male rhesus monkeys, oral administration of PQCA (3-30 mg/kg) effectively mitigates the cognitive impairments induced by scopolamine in both the paired-associates learning (PAL) and the continuous performance task (CPT). Scopolamine-induced blockade of muscarinic signaling results in significant deficits in performance on both tasks. [1] |
分子量 | 388.42 |
分子式 | C22H20N4O3 |
CAS No. | 1144504-35-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 9.0 mg/mL (23.2 mM), Sonication and heating to 80℃ are recommended.
You can also refer to dose conversion for different animals. 詳細
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PQCA 1144504-35-7 Neuroscience Others AChR Inhibitor inhibitor inhibit