Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Picolinamide (Picolinoylamide) is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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25 mg | 在庫あり | ¥ 7,000 | |||
50 mg | 在庫あり | ¥ 10,000 | |||
100 mg | 在庫あり | ¥ 13,500 | |||
200 mg | 在庫あり | ¥ 22,000 | |||
250 mg | 在庫あり | ¥ 28,500 | |||
500 mg | 在庫あり | ¥ 41,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 10,500 |
説明 | Picolinamide (Picolinoylamide) is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells. |
ターゲット&IC50 | PARP:95 μM |
In vitro | In AR-HEK293 cells stably expressing full-length hAR, ODM-201 inhibits human AR (hAR) with IC50 of 26 nM. ODM-201 inhibits VCaP cell proliferation with IC50 of 230 nM, while has no effect on the viability of AR-negative cell lines tested, DU-145 prostate cancer cells and H1581 lung cancer cells. [1] |
In vivo | Overnight treatment of rats with picolinamide, administered as a single injection (4 mmol/kg), inhibits Na+/phosphate cotransport by isolated renal brush border membrane vesicles. There is only a small increase (1.5-fold) in renal cortical NAD content after picolinamide treatment[3]. |
別名 | 2-Pyridinecarboxamide, 2-Carbamoylpyridine, 2-Picolinamide, Picolinoylamide |
分子量 | 122.12 |
分子式 | C6H6N2O |
CAS No. | 1452-77-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 23 mg/mL (188.3 mM)
DMSO: 45 mg/mL (368.49 mM)
H2O: 22 mg/mL (180.2 mM)
You can also refer to dose conversion for different animals. 詳細
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Picolinamide 1452-77-3 Chromatin/Epigenetic DNA Damage/DNA Repair PARP 2-Pyridinecarboxamide 2-Carbamoylpyridine 2-Picolinamide Picolinoylamide Inhibitor inhibitor inhibit