Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RIPGBM is a selective inducer of apoptosis in glioblastoma multiforme cancer stem cells (EC50: ≤500 nM).
説明 | RIPGBM is a selective inducer of apoptosis in glioblastoma multiforme cancer stem cells (EC50: ≤500 nM). |
ターゲット&IC50 | Apoptosis (GBM CSCs):(EC50)≤500 nM |
In vitro | RIPGBM causes caspase 1-dependent apoptosis by binding to receptor-interacting protein kinase 2 and acting as a molecular switch. It reduces the formation of a prosurvival RIPK2/ TAK1 complex and increases the formation of a proapoptotic RIPK2/caspase 1 complex [1]. |
分子量 | 428.45 |
分子式 | C26H21FN2O3 |
CAS No. | 355406-76-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (70.02 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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RIPGBM 355406-76-7 Apoptosis inhibit Inhibitor inhibitor